Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with
liver or brain metastasis have an extremely poor prognosis and low response rates to anti …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Background & Aims Regulatory T-cells (Tregs) impair cancer immunosurveillance by
creating an immunosuppressive environment that fosters tumor cell survival. Our previous …

Pathophysiology of Inflammatory Bowel Diseases Research on IBDs has identified disrupted
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …

Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …