The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …

T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …

Background Current staging methods are inadequate for predicting the outcome of treatment
of non–small-cell lung cancer (NSCLC). We developed a five-gene signature that is closely …

A healthy individual can mount an immune response to exogenous pathogens while
avoiding an autoimmune attack on normal tissues. The ability to distinguish between self …

Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is
upregulated on the surface of T cells following T cell activation and upon binding to its ligand …

T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen
because it activates the Src family kinase Lck, which phosphorylates the T cell antigen …

Plant products in general and soybeans in particular can challenge the function and health
of the intestinal tract. Salmonids develop an intestinal inflammation when fed diets …

SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain
multiple protein-binding domains. These proteins are essential for signalling downstream of …

Although immunotherapy has emerged as an effective therapeutic strategy for various
cancers including head and neck squamous cell carcinomas (HNSCCs), only a subset of …

Glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressant agents.
Unfortunately, they also produce serious side effects that limit their usage. This discrepancy …