Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Physiology and diseases of tissue-resident macrophages

T Lazarov, S Juarez-Carreño, N Cox, F Geissmann - Nature, 2023 - nature.com
Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts

Y Wang, H Zhang, C Liu, Z Wang, W Wu… - Journal of Hematology & …, 2022 - Springer
The discovery of immune checkpoint inhibitors (ICIs) has now been universally
acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of …

Pharmacological targeting of endoplasmic reticulum stress in disease

SJ Marciniak, JE Chambers, D Ron - Nature reviews Drug discovery, 2022 - nature.com
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma

P Zhang, A Rashidi, J Zhao, C Silvers, H Wang… - Nature …, 2023 - nature.com
As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here …

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

J Theruvath, M Menard, BAH Smith, MH Linde… - Nature medicine, 2022 - nature.com
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal
antibodies targeting GD2 have substantially improved outcomes for children with high-risk …

Emerging phagocytosis checkpoints in cancer immunotherapy

Y Liu, Y Wang, Y Yang, L Weng, Q Wu… - Signal transduction and …, 2023 - nature.com
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

[HTML][HTML] Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

L Galluzzi, I Vitale, S Warren, S Adjemian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

The clearance of dead cells by efferocytosis

E Boada-Romero, J Martinez, BL Heckmann… - … reviews Molecular cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

M McLaughlin, EC Patin, M Pedersen, A Wilkins… - Nature Reviews …, 2020 - nature.com
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …