Mood disorders are common and debilitating, resulting in a significant public health burden.
Current treatments are only partly effective and patients who have failed to respond to trials …

The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in
several case reports and open studies, which is thought to act by inhibiting glutamate …

Objective: Lamotrigine is one of the pharmacologic options for the treatment of bipolar
depression but has only been studied as monotherapy. This study compared the acute …

Clinical and experimental evidence suggest that estrogens have a major impact on
cognition, presenting neurotrophic and neuroprotective actions in regions involved in such …

Catalpol is a major compound in Rehmanniae Radix with outstanding medicinal and
nutritional values. Our previous studies have demonstrated catalpol's antidepressant effect …

This study tested the potential antidepressant activity of minocycline alone or combined with
two traditional antidepressant drugs or several glutamate receptor antagonists, using the …

Over 80% of current anxiety studies employ one of the tests that were developed earlier
than, or concurrently with the elevated plus-maze, ie before 1985. Considering 1985 as a …

The present study was designed to assess the effect of dexamethasone, a synthetic
glucocorticoid receptor agonist, in the sucrose preference test in rats. Rats treated acutely …

The most common features of Parkinson's disease (PD) are motor impairments, but many
patients also present depression and memory impairment. Ketamine, an N-methyl-d …

Anand A, Gunn AD, Barkay G, Karne HS, Nurnberger JI, Mathew SJ, Ghosh S. Early
antidepressant effect of memantine during augmentation of lamotrigine inadequate …