Novel glutamatergic drugs for the treatment of mood disorders
KAB Lapidus, L Soleimani… - … disease and treatment, 2013 - Taylor & Francis
Mood disorders are common and debilitating, resulting in a significant public health burden.
Current treatments are only partly effective and patients who have failed to respond to trials …
Current treatments are only partly effective and patients who have failed to respond to trials …
[HTML][HTML] Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer
KS Prabhavalkar, NB Poovanpallil… - Frontiers in …, 2015 - frontiersin.org
The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in
several case reports and open studies, which is thought to act by inhibiting glutamate …
several case reports and open studies, which is thought to act by inhibiting glutamate …
Efficacy and safety of lamotrigine as add-on treatment to lithium in bipolar depression: a multicenter, double-blind, placebo-controlled trial.
MLM van der Loos, PGH Mulder… - Journal of Clinical …, 2009 - psychiatrist.com
Objective: Lamotrigine is one of the pharmacologic options for the treatment of bipolar
depression but has only been studied as monotherapy. This study compared the acute …
depression but has only been studied as monotherapy. This study compared the acute …
17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant …
Á Kiss, AM Delattre, SIR Pereira, RG Carolino… - Behavioural brain …, 2012 - Elsevier
Clinical and experimental evidence suggest that estrogens have a major impact on
cognition, presenting neurotrophic and neuroprotective actions in regions involved in such …
cognition, presenting neurotrophic and neuroprotective actions in regions involved in such …
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus
J Wang, R Chen, C Liu, X Wu, Y Zhang - European journal of pharmacology, 2021 - Elsevier
Catalpol is a major compound in Rehmanniae Radix with outstanding medicinal and
nutritional values. Our previous studies have demonstrated catalpol's antidepressant effect …
nutritional values. Our previous studies have demonstrated catalpol's antidepressant effect …
Antidepressant-like actions of minocycline combined with several glutamate antagonists
M Molina-Hernández, NP Tellez-Alcántara… - Progress in Neuro …, 2008 - Elsevier
This study tested the potential antidepressant activity of minocycline alone or combined with
two traditional antidepressant drugs or several glutamate receptor antagonists, using the …
two traditional antidepressant drugs or several glutamate receptor antagonists, using the …
Classical and novel approaches to the preclinical testing of anxiolytics: a critical evaluation
Over 80% of current anxiety studies employ one of the tests that were developed earlier
than, or concurrently with the elevated plus-maze, ie before 1985. Considering 1985 as a …
than, or concurrently with the elevated plus-maze, ie before 1985. Considering 1985 as a …
Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone
PC Casarotto, R Andreatini - European Neuropsychopharmacology, 2007 - Elsevier
The present study was designed to assess the effect of dexamethasone, a synthetic
glucocorticoid receptor agonist, in the sucrose preference test in rats. Rats treated acutely …
glucocorticoid receptor agonist, in the sucrose preference test in rats. Rats treated acutely …
[HTML][HTML] Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease
D Dalla Vecchia, LKS Kanazawa, E Wendler… - Brain Research …, 2021 - Elsevier
The most common features of Parkinson's disease (PD) are motor impairments, but many
patients also present depression and memory impairment. Ketamine, an N-methyl-d …
patients also present depression and memory impairment. Ketamine, an N-methyl-d …
Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double‐blind, randomized, placebo …
A Anand, AD Gunn, G Barkay, HS Karne… - Bipolar …, 2012 - Wiley Online Library
Anand A, Gunn AD, Barkay G, Karne HS, Nurnberger JI, Mathew SJ, Ghosh S. Early
antidepressant effect of memantine during augmentation of lamotrigine inadequate …
antidepressant effect of memantine during augmentation of lamotrigine inadequate …