Background Breast cancer is defined as a biological and molecular heterogeneous disorder
that originates from breast cells. Genetic predisposition is the most important factor giving …

Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Overexpression of histone deacetylase (HDAC) isoforms has been implicated in a variety of
disease pathologies, from cancer and colitis to cardiovascular disease and …

Abstract N6-methyladenosine (m6A) modification plays important roles in bioprocesses and
diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases. Here, we reveal that …

Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Proteolysis targeting chimaeras (PROTACs) is a cutting edge and rapidly growing technique
for new drug discovery and development. Currently, the largest challenge in the molecular …

Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Abstract Histone deacetylase 3 (HDAC3) is an epigenetic regulator that involves gene
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …

Breast cancer is a common cancer that occurs due to different epigenetic alterations and
genetic mutations. Various epidemiological studies have demonstrated an inverse …