Receptor-targeting peptides have been extensively pursued for improving binding specificity
and effective accumulation of drugs at the site of interest, and have remained challenging for …

Abstract Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the
degradation of intracellular proteins in lysosomes, is upregulated in tumors for pro …

Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is
greatly effective in melanoma treatment, low response rate and treatment resistance …

Currently, the therapeutic performance of traditional mono-chemotherapy on cancers
remains unsatisfactory because of the tumor heterogeneity and multidrug resistance. In light …

Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …

As alternatives to small-molecular proteolysis-targeting chimeras (PROTAC), peptide-based
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …

Androgen receptor splice variant‐7 (AR‐V7), one of the major driving factors, is the most
attractive drug target in castration‐resistant prostate cancer (CRPC). Currently, no available …

Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …

Despite recent advances in treatment, overall survival rates for metastatic melanoma,
especially those that invade the lungs, continue to be low, with 5-year survival rates of only …

药物递送系统是将药物输送到药物作用靶点的系统, 理想的递送系统可以提高药物作用效果并
降低给药剂量和毒副作用. 本文综述了药物递送系统中的多肽类药物递送系统的研究进展 …