[HTML][HTML] Peptide-enabled targeted delivery systems for therapeutic applications
M Liu, X Fang, Y Yang, C Wang - Frontiers in bioengineering and …, 2021 - frontiersin.org
Receptor-targeting peptides have been extensively pursued for improving binding specificity
and effective accumulation of drugs at the site of interest, and have remained challenging for …
and effective accumulation of drugs at the site of interest, and have remained challenging for …
[HTML][HTML] Rewiring chaperone-mediated autophagy in cancer by a prion-like chemical inducer of proximity to counteract adaptive immune resistance
J Yan, D Liu, J Wang, W You, W Yang, S Yan… - Drug Resistance …, 2024 - Elsevier
Abstract Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the
degradation of intracellular proteins in lysosomes, is upregulated in tumors for pro …
degradation of intracellular proteins in lysosomes, is upregulated in tumors for pro …
[HTML][HTML] Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis
W Guo, Z Wu, J Chen, S Guo, W You… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is
greatly effective in melanoma treatment, low response rate and treatment resistance …
greatly effective in melanoma treatment, low response rate and treatment resistance …
Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy
R Bholakant, B Dong, X Zhou, X Huang… - Journal of Materials …, 2021 - pubs.rsc.org
Currently, the therapeutic performance of traditional mono-chemotherapy on cancers
remains unsatisfactory because of the tumor heterogeneity and multidrug resistance. In light …
remains unsatisfactory because of the tumor heterogeneity and multidrug resistance. In light …
[HTML][HTML] Turning chiral peptides into a racemic supraparticle to induce the self-degradation of MDM2
Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …
pharmacological action through chiral matching with biomolecules and molecular …
[HTML][HTML] A nano-predator of pathological MDMX construct by clearable supramolecular gold (I)-thiol-peptide complexes achieves safe and potent anti-tumor activity
S Yan, J Yan, D Liu, X Li, Q Kang, W You, J Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
As alternatives to small-molecular proteolysis-targeting chimeras (PROTAC), peptide-based
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …
De novo design of an androgen receptor DNA binding domain‐targeted peptide PROTAC for prostate cancer therapy
B Ma, Y Fan, D Zhang, Y Wei, Y Jian, D Liu… - Advanced …, 2022 - Wiley Online Library
Androgen receptor splice variant‐7 (AR‐V7), one of the major driving factors, is the most
attractive drug target in castration‐resistant prostate cancer (CRPC). Currently, no available …
attractive drug target in castration‐resistant prostate cancer (CRPC). Currently, no available …
[HTML][HTML] Turing milk into pro-apoptotic oral nanotherapeutic: De novo bionic chiral-peptide supramolecule for cancer targeted and immunological therapy
W He, Z Zhang, W Yang, X Zheng, W You, Y Yao… - Theranostics, 2022 - ncbi.nlm.nih.gov
Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …
chiral peptides are extremely rare, principally because of the immature nanofabrication and …
[HTML][HTML] A de novo dual-targeting supramolecular self-assembly peptide against pulmonary metastasis of melanoma
Despite recent advances in treatment, overall survival rates for metastatic melanoma,
especially those that invade the lungs, continue to be low, with 5-year survival rates of only …
especially those that invade the lungs, continue to be low, with 5-year survival rates of only …
基于多肽的药物递送系统研究进展
李怡静, 龚雪峰, 王冬, 杨洲, 曹晖, 王磊 - 高分子学报, 2023 - gfzxb.org
药物递送系统是将药物输送到药物作用靶点的系统, 理想的递送系统可以提高药物作用效果并
降低给药剂量和毒副作用. 本文综述了药物递送系统中的多肽类药物递送系统的研究进展 …
降低给药剂量和毒副作用. 本文综述了药物递送系统中的多肽类药物递送系统的研究进展 …