As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …

Angiogenesis plays a key role in the wound healing process, involving the migration,
growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance …

Angiogenin is an angiogenic protein that undergoes nuclear translocation in endothelial
cells where it accumulates in the nucleolus and stimulates rRNA transcription, a rate-limiting …

Angiogenin induces angiogenesis by activating vessel endothelial and smooth muscle cells
and triggering a number of biological processes, including cell migration, invasion …

In this review we discuss the concept of anti-angiogenesis, which is the inhibition of
neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on …

The intracellular pathway of human angiogenin in calf pulmonary artery endothelial (CPAE)
cells has been studied by immunofluorescence microscopy. Proliferating CPAE cells …

Angiogenin is a member of the ribonuclease (RNase) superfamily: enzymes of innate
substrate specificity, but divergent functional capacities. Angiogenin is a normal constituent …

Onconase, or P-30, is a protein initially purified from extracts of Rana pipiens oocytes and
early embryos based upon its anticancer activity both in vitro and in vivo. It is a basic single …

Angiogenin stimulates both [3H] thymidine incorporation and proliferation of human
endothelial cells in sparse cultures. Under these conditions, a 170-kDa cell surface protein …

Angiogenesis in vivo is distinguished by four stages: subsequent to the transduction of
signals to differentiate, stage 1 is defined as an altered proteolytic balance of the cell …