Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …

Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

In contrast to pain processing neurons in the spinal cord, where the importance of chloride
conductances is already well established, chloride homeostasis in primary afferent neurons …

Abstract Bestrophin-1 (Best1) is a calcium-activated anion channel identified from retinal
pigment epithelium where human mutations are associated with Best's macular …

Increasing evidence suggests that transmembrane protein 16A (TMEM16A) in nociceptive
neurons is an important molecular component contributing to peripheral pain transduction …

The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction
following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells …

Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1),
also known as TMEM16A. ANO1 allows the passive chloride flux that controls different …

Background The purpose of this study was to evaluate the participation of satellite glial cells
(SGC), microglia and astrocytes in a model of streptozotocin-induced diabetes initiated in …

Abstract Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in
nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local …