HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose
expression is strongly correlated with the tumor grade and prognosis of a variety of …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …

Breast cancer (BC), a heterogeneous group of diseases, is the most frequent type and the
leading cause of cancer-related death among women worldwide. Tumor heterogeneity …

Background Despite technological advances in radiotherapy, cancer cells at the tumor
margin and in diffusive infiltrates can receive subcytotoxic doses of photons. Even if only a …

Triple-negative breast cancer (TNBC) is a more aggressive type of breast cancer due to its
heterogeneity and complex molecular mechanisms. TNBC has a high risk for metastasis …

Background The ubiquitin protein ligase E3C (UBE3C) has been reported to play an
oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C …

The extensive heterogeneity and the limited availability of effective targeted therapies
contribute to the challenging prognosis and restricted survival observed in triple-negative …

Enhanced understanding of the molecular basis of radioresistance paves the way for novel
therapeutic interventions, potentially translatable into clinical applications. This section …

Radiotherapy has an essential role in breast cancer treatment. However, tumor cells may be
resistant to radiotherapy. Noncoding RNAs are considered regulators of different pathways …