An overview of microRNAs

SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

Methods of MicroRNA promoter prediction and transcription factor mediated regulatory network

Y Zhao, F Wang, S Chen, J Wan… - BioMed research …, 2017 - Wiley Online Library
MicroRNAs (miRNAs) are short (~ 22 nucleotides) noncoding RNAs and disseminated
throughout the genome, either in the intergenic regions or in the intronic sequences of …

Multiobjective binary biogeography based optimization for feature selection using gene expression data

X Li, M Yin - IEEE Transactions on NanoBioscience, 2013 - ieeexplore.ieee.org
Gene expression data play an important role in the development of efficient cancer
diagnoses and classification. However, gene expression data are usually redundant and …

[HTML][HTML] Comparison of five supervised feature selection algorithms leading to top features and gene signatures from multi-omics data in cancer

T Bhadra, S Mallik, N Hasan, Z Zhao - BMC bioinformatics, 2022 - Springer
Background As many complex omics data have been generated during the last two
decades, dimensionality reduction problem has been a challenging issue in better mining …

A heuristic algorithm for identifying molecular signatures in cancer

Y Su, S Li, C Zheng, X Zhang - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
Molecular signatures of cancer, eg, genes or microRNAs (miRNAs), have been recognized
very important in predicting the occurrence of cancer. From gene-expression and miRNA …

Analyses of microRNA166 gene structure, expression, and function during the early stage of somatic embryogenesis in Dimocarpus longan Lour

QL Zhang, LY Su, ST Zhang, XP Xu, XH Chen… - Plant Physiology and …, 2020 - Elsevier
Abstract MicroRNA166 (miR166) contributes to post-transcriptional regulation by binding the
mRNAs of HD-ZIP III genes, which affects plant growth and development. The structural …

Regulation of miRNA processing and miRNA mediated gene repression in cancer

S Bajan, G Hutvagner - Microrna, 2014 - ingentaconnect.com
The majority of human protein-coding genes are predicted to be targets of miRNA-mediated
posttranscriptional regulation. The widespread influence of miRNAs is illustrated by their …

Multi-objective simplified swarm optimization with weighting scheme for gene selection

CM Lai - Applied Soft Computing, 2018 - Elsevier
Gene selection can be regarded as a multi-objective problem which involves both
minimizing the size of a gene subset and maximizing the prediction performance. This work …

Machine learning strategies in microRNA research: bridging genome to phenome

S Daniel Thomas, K Vijayakumar, L John… - OMICS: A Journal of …, 2024 - liebertpub.com
MicroRNAs (miRNAs) have emerged as a prominent layer of regulation of gene expression.
This article offers the salient and current aspects of machine learning (ML) tools and …

Nature-inspired multiobjective cancer subtype diagnosis

Y Wang, B Liu, Z Ma, KC Wong… - IEEE journal of …, 2019 - ieeexplore.ieee.org
Cancer gene expression data is of great importance in cancer subtype diagnosis and drug
discovery. Many computational methods have been proposed to classify subtypes using …