Butyrate shapes immune cell fate and function in allergic asthma

W Yip, MR Hughes, Y Li, A Cait, M Hirst… - Frontiers in …, 2021 - frontiersin.org
The microbiome plays a fundamental role in how the immune system develops and how
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

A Cait, MR Hughes, F Antignano, J Cait… - Mucosal …, 2018 - nature.com
The mammalian gastrointestinal tract harbors a microbial community with metabolic activity
critical for host health, including metabolites that can modulate effector functions of immune …

Effects of flavonoids and its derivatives on immune cell responses

G Martínez, MR Mijares… - Recent Patents on …, 2019 - ingentaconnect.com
Background: Various pieces of evidence have shown that people who consume foods rich in
polyphenolic and flavonoids compounds have a lower incidence of inflammatory …

Mast cells as drivers of disease and therapeutic targets

F Siebenhaar, FA Redegeld, SC Bischoff, BF Gibbs… - Trends in …, 2018 - cell.com
Mast cells (MCs) contribute to the pathogenesis of a multitude of diseases that include MC-
driven disorders such as urticaria, type I allergies, and mastocytosis as well as autoimmune …

Malignant transformation of oral submucous fibrosis: overview of histopathological aspects

JG Ray, K Ranganathan, A Chattopadhyay - Oral surgery, oral medicine …, 2016 - Elsevier
Oral submucous fibrosis (OSF), first described in 1952, is a potentially malignant disorder
associated with betel quid and areca nut chewing, mostly prevalent in the population of the …

Mast cell chymase: morphofunctional characteristics

D Atiakshin, I Buchwalow, M Tiemann - Histochemistry and Cell Biology, 2019 - Springer
During degranulation, mast cells secrete a specific set of mediators defined as “secretome”
including the preformed mediators that have already been synthesized by a cell and …

Clinical impact and proposed application of molecular markers, genetic variants, and cytogenetic analysis in mast cell neoplasms: Status 2022

M Arock, G Hoermann, K Sotlar, O Hermine… - Journal of Allergy and …, 2022 - Elsevier
Mast cell neoplasms are an emerging challenge in the fields of internal medicine, allergy,
immunology, dermatology, laboratory medicine, and pathology. In this review, we discuss …

Masitinib for the treatment of mild to moderate Alzheimer's disease

J Folch, D Petrov, M Ettcheto, I Pedros… - Expert review of …, 2015 - Taylor & Francis
Alzheimer's disease (AD) is a degenerative neurological disorder that is the most common
cause of dementia and disability in older patients. Available treatments are symptomatic in …

The mast cell–B cell axis in lung vascular remodeling and pulmonary hypertension

S Breitling, Z Hui, D Zabini, Y Hu… - … of Physiology-Lung …, 2017 - journals.physiology.org
Over past years, a critical role for the immune system and, in particular, for mast cells in the
pathogenesis of pulmonary hypertension (PH) has emerged. However, the way in which …

Mast cell proteases activate astrocytes and glia-neurons and release interleukin-33 by activating p38 and ERK1/2 MAPKs and NF-κB

D Kempuraj, R Thangavel, GP Selvakumar… - Molecular …, 2019 - Springer
Inflammatory mediators released from activated microglia, astrocytes, neurons, and mast
cells mediate neuroinflammation. Parkinson's disease (PD) is characterized by inflammation …