Thalassaemia is a diverse group of genetic disorders with a worldwide distribution affecting
globin chain synthesis. The pathogenesis of thalassaemia lies in the unbalanced globin …

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike
patients with beta (β)-thalassemia major, do not require regular transfusion therapy for …

Red blood cell (RBC) transfusion is a key treatment of patients with sickle cell disease (SCD)
but remains complicated by RBC immunization. In the present study, we evaluated the …

Transfusions can be a life-saving treatment of patients with sickle-cell disease (SCD).
However, availability of matched units can be limiting because of distinctive blood group …

Red cell transfusion remains a critical component of care for acute and chronic
complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of …

Sickle cell disease (SCD) is an inherited blood disorder characterized by sickled red blood
cells (RBCs), which are more sensitive to haemolysis and can contribute to disease …

Transfusion therapy is a key intervention in decreasing morbidity and mortality in patients
with sickle cell disease (SCD). Current indications for acute and chronic transfusion therapy …

Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia
(SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic …

RH genes are highly polymorphic and encode the most complex of the 35 human blood
group systems. This genetic diversity contributes to Rh alloimmunization in patients with …

Alloimmunization against red blood cell (RBC) antigens is a cause of morbidity and mortality
in transfused patients with sickle cell disease (SCD). To investigate distinguishing …