▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …

Use of model systems to explore the forces that control β sheet formation was stymied for
many years by the perception that small increments of β sheet necessarily aggregate …

We have developed a statistical mechanics algorithm, TANGO, to predict protein
aggregation. TANGO is based on the physico-chemical principles of β-sheet formation …

Background In the past, many methods have been developed for peptide tertiary structure
prediction but they are limited to peptides having natural amino acids. This study describes a …

The information about the conformational behavior of monomeric helical peptides in
solution, as well as the α-helix stability in proteins, has been previously utilized to derive a …

Peptidyl-prolyl cis/trans isomerisation has been frequently found as a rate limiting step in the
folding of proteins. In order to determine whether the nature of the amino acid preceding …

Islet amyloid polypeptide (IAPP) contributes to the pathogenesis of type II diabetes by
depositing as cytotoxic amyloid fibers in the endocrine pancreas. Fiber formation occurs with …

Abstract AHTPDB (http://crdd. osdd. net/raghava/ahtpdb/) is a manually curated database of
experimentally validated antihypertensive peptides. Information pertaining to peptides with …

A 20-residue protein (named Betanova) forming a monomeric, three-stranded, antiparallel β
sheet was designed using a structural backbone template and an iterative hierarchical …

Protein folding barriers result from a combination of factors including unavoidable energetic
frustration from nonnative interactions, natural variation and selection of the amino acid …