Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2)
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …

Protein misfolding and aggregation is a common hallmark in neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and fronto-temporal dementia …

Genetic studies have provided valuable insight into the pathological mechanisms underlying
Parkinson's disease (PD). The elucidation of genetic components to what was once largely …