Muscles are the major force producing tissue in the human body. While certain muscle types
specialize in producing maximum forces, others are very enduring. An extreme example is …

Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the
sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin …

The Drosophila genome contains> 13000 protein-coding genes, the majority of which
remain poorly investigated. Important reasons include the lack of antibodies or reporter …

Complex animals build specialised muscles to match specific biomechanical and energetic
needs. Hence, composition and architecture of sarcomeres and mitochondria are muscle …

Background Skeletal muscle development is a multistep process whose understanding is
central in a broad range of fields and applications, from the potential medical value to …

Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-
producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics …

Animals possess a wide variety of muscle types that support different kinds of movements.
Different muscles have distinct locations, morphologies and contractile properties, raising …

Sarcomeres are the force-producing units of all striated muscles. Their nanoarchitecture
critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z …

Abstract Analysis of gene function in complex organisms relies extensively on tools to detect
the cellular and subcellular localization of gene products, especially proteins. Typically …

Measuring the positions and dynamics of proteins in intact tissues or whole animals is key to
understanding protein function. However, to date, this is challenging, as the accessibility of …