Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing
The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …
Computational methods for the aortic heart valve and its replacements
Introduction: Replacement with a prosthetic device remains a major treatment option for the
patients suffering from heart valve disease, with prevalence growing resulting from an …
patients suffering from heart valve disease, with prevalence growing resulting from an …
A framework for designing patient‐specific bioprosthetic heart valves using immersogeometric fluid–structure interaction analysis
F Xu, S Morganti, R Zakerzadeh… - … journal for numerical …, 2018 - Wiley Online Library
Numerous studies have suggested that medical image derived computational mechanics
models could be developed to reduce mortality and morbidity due to cardiovascular …
models could be developed to reduce mortality and morbidity due to cardiovascular …
On the modeling of patient-specific transcatheter aortic valve replacement: a fluid–structure interaction approach
Purpose Transcatheter aortic valve replacement (TAVR) is a minimally invasive treatment for
high-risk patients with aortic diseases. Despite its increasing use, many influential factors …
high-risk patients with aortic diseases. Despite its increasing use, many influential factors …
An ultrasound-exclusive non-invasive computational diagnostic framework for personalized cardiology of aortic valve stenosis
Aortic stenosis (AS) is an acute and chronic cardiovascular disease and If left untreated,
50% of these patients will die within two years of developing symptoms. AS is characterized …
50% of these patients will die within two years of developing symptoms. AS is characterized …
A deep learning framework for design and analysis of surgical bioprosthetic heart valves
A Balu, S Nallagonda, F Xu, A Krishnamurthy… - Scientific reports, 2019 - nature.com
Bioprosthetic heart valves (BHVs) are commonly used as heart valve replacements but they
are prone to fatigue failure; estimating their remaining life directly from medical images is …
are prone to fatigue failure; estimating their remaining life directly from medical images is …
Parameterization, algorithmic modeling, and fluid–structure interaction analysis for generative design of transcatheter aortic valves
Heart valves play a critical role in maintaining proper cardiovascular function in the human
heart; however, valve diseases can lead to improper valvular function and reduced …
heart; however, valve diseases can lead to improper valvular function and reduced …
Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium
The durability of bovine pericardium leaflets employed in bioprosthetic heart valves (BHVs)
can significantly limit the longevity of heart valve prostheses. Collagen fibres are the …
can significantly limit the longevity of heart valve prostheses. Collagen fibres are the …
Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves
EL Johnson, DW Laurence, F Xu, CE Crisp… - Computer methods in …, 2021 - Elsevier
Approximately 1.6 million patients in the United States are affected by tricuspid valve
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …
Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …