Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

AS Correia, N Vale - International journal of molecular sciences, 2022 - mdpi.com
Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

Mechanisms underlying neurodegenerative disorders and potential neuroprotective activity of agrifood by-products

C Angeloni, M Malaguti, C Prata, M Freschi… - Antioxidants, 2022 - mdpi.com
Neurodegenerative diseases, characterized by progressive loss in selected areas of the
nervous system, are becoming increasingly prevalent worldwide due to an aging population …

Natural products inhibitors of monoamine oxidases—Potential new drug leads for neuroprotection, neurological disorders, and neuroblastoma

ND Chaurasiya, F Leon, I Muhammad, BL Tekwani - Molecules, 2022 - mdpi.com
Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for
treatment of depression and other neurological disorders. Evidence has suggested that …

Mechanisms of dopamine oxidation and Parkinson's disease

J Segura-Aguilar, I Paris - Handbook of neurotoxicity, 2022 - Springer
Dopamine's ability to oxidize to aminochrome explains why this molecule may be a
neurotoxic compound that induces toxicity in both cell lines and animal models …

Sympathetic Nervous System and Atherosclerosis

Y Wang, J Anesi, MC Maier, MA Myers… - International journal of …, 2023 - mdpi.com
Atherosclerosis is characterized by the narrowing of the arterial lumen due to subendothelial
lipid accumulation, with hypercholesterolemia being a major risk factor. Despite the recent …

Corpora cavernosa fibroblasts mediate penile erection

EL Guimaraes, DO Dias, WF Hau, A Julien, D Holl… - Science, 2024 - science.org
Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that
enlarges upon vasodilation, but its regulation is not completely understood. Here, we show …

The role of pharmacogenetics in personalizing the antidepressant and anxiolytic therapy

M Radosavljevic, D Svob Strac, J Jancic, J Samardzic - Genes, 2023 - mdpi.com
Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been
characterized by significant inter-individual variability in drug response and the development …

Anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating SIRT1 signaling pathway in senescent …

Z Zeng, C Chen, Y SiTu, Z Shen, Y Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Anoectochilus roxburghii (A. roxburghii) is a precious herb
and folk medicine in many Asian countries. It has been used traditionally to treat diabetes …

Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy

M Fantacuzzi, R Amoroso, S Carradori… - European Journal of …, 2022 - Elsevier
Neurodegenerative diseases (NDs) are characterized by gradual and progressive loss of
selectively vulnerable populations of neurons, including death of neurons in different …

Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron

AO Adedara, TA Otenaike, AA Olabiyi, IA Adedara… - Metabolic Brain …, 2023 - Springer
Exposure to environmental toxicants has been linked with the onset of different
neurodegenerative diseases in animals and humans. Here, we evaluated the toxic effects of …