DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Mutations in the promoter of the telomerase reverse transcriptase (TERT) and fibroblast
growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in …

Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …

Background Currently, telomere length is known to reflect the replication potential and
longevity of cells, and many studies have reported that telomere length is associated with …

Objective To summarise and discuss the association between telomerase activity and
psychological stress, mental disorders and lifestyle factors. Method A systematic review was …

Malignant pleural mesothelioma (MPM) is a very aggressive tumor with no known curative
treatment. Better knowledge of the molecular mechanisms of mesothelial carcinogenesis is …