[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …
information and translation of the genetic code into proteins, DNA holds great promise as a …
TERT promoter mutations in telomere biology
B Heidenreich, R Kumar - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …
TERT promoter mutations in cancer development
B Heidenreich, PS Rachakonda, K Hemminki… - Current opinion in …, 2014 - Elsevier
Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …
Telomeres, telomerase and ageing
G Saretzki - Biochemistry and Cell Biology of Ageing: Part I …, 2018 - Springer
Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …
Telomere and telomerase biology
Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …
Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer
I Hosen, PS Rachakonda, B Heidenreich… - … journal of cancer, 2015 - Wiley Online Library
Mutations in the promoter of the telomerase reverse transcriptase (TERT) and fibroblast
growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in …
growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in …
Therapeutic strategies for targeting telomerase in cancer
X Chen, WJ Tang, JB Shi, MM Liu… - Medicinal research …, 2020 - Wiley Online Library
Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …
Association between dietary vitamin C and telomere length: A cross-sectional study
Y Cai, Y Zhong, H Zhang, P Lu, Y Liang, B Hu… - Frontiers in …, 2023 - frontiersin.org
Background Currently, telomere length is known to reflect the replication potential and
longevity of cells, and many studies have reported that telomere length is associated with …
longevity of cells, and many studies have reported that telomere length is associated with …
Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review
W Deng, ST Cheung, SW Tsao, XM Wang… - …, 2016 - Elsevier
Objective To summarise and discuss the association between telomerase activity and
psychological stress, mental disorders and lifestyle factors. Method A systematic review was …
psychological stress, mental disorders and lifestyle factors. Method A systematic review was …
Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma
A Tallet, JC Nault, A Renier, I Hysi, F Galateau-Salle… - Oncogene, 2014 - nature.com
Malignant pleural mesothelioma (MPM) is a very aggressive tumor with no known curative
treatment. Better knowledge of the molecular mechanisms of mesothelial carcinogenesis is …
treatment. Better knowledge of the molecular mechanisms of mesothelial carcinogenesis is …