Vaccines for human fungal diseases: close but still a long way to go

LVN Oliveira, R Wang, CA Specht, SM Levitz - npj Vaccines, 2021 - nature.com
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments

AF Valdez, DZ Miranda, AJ Guimarães, L Nimrichter… - Virulence, 2022 - Taylor & Francis
Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus
Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the …

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

J Rizzo, SSW Wong, AD Gazi… - Journal of …, 2021 - Wiley Online Library
Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

Extracellular Vesicles from Fusarium graminearum Contain Protein Effectors Expressed during Infection of Corn

D Garcia-Ceron, RGT Lowe, JA McKenna, LM Brain… - Journal of Fungi, 2021 - mdpi.com
Fusarium graminearum (Fgr) is a devastating filamentous fungal pathogen that causes
diseases in cereals, while producing mycotoxins that are toxic for humans and animals, and …

Vaccines against candidiasis: Status, challenges and emerging opportunity

SR Sahu, S Bose, M Singh, P Kumari… - Frontiers in Cellular …, 2022 - frontiersin.org
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of
fungal infections has considerably increased in the last few years primarily due to an …

Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles

W Chan, FWN Chow, CC Tsang, X Liu… - Emerging Microbes & …, 2022 - Taylor & Francis
Drug resistance derived from extracellular vesicles (EVs) is an increasingly important
research area but has seldom been described regarding fungal pathogens. Here, we …

Comparative molecular and immunoregulatory analysis of extracellular vesicles from Candida albicans and Candida auris

D Zamith-Miranda, HM Heyman, SP Couvillion… - Msystems, 2021 - Am Soc Microbiol
Candida auris is a recently described multidrug-resistant pathogenic fungus that is
increasingly responsible for health care-associated outbreaks across the world …

Insight Into the Properties and Immunoregulatory Effect of Extracellular Vesicles Produced by Candida glabrata, Candida parapsilosis, and Candida tropicalis …

K Kulig, E Karnas, O Woznicka, P Kuleta… - Frontiers in cellular …, 2022 - frontiersin.org
Currently, non-albicans Candida species, including C. tropicalis, C. glabrata, and C.
parapsilosis, are becoming an increasing epidemiological threat, predominantly due to the …

Candida albicans hyphal extracellular vesicles are different from yeast ones, carrying an active proteasome complex and showing a different role in host immune …

R Martínez-López, ML Hernáez, E Redondo… - Microbiology …, 2022 - Am Soc Microbiol
Candida albicans is the principal causative agent of lethal fungal infections, predominantly
in immunocompromised hosts. Extracellular vesicles (EVs) have been described as crucial …

Extracellular Vesicles Derived From Talaromyces marneffei Yeasts Mediate Inflammatory Response in Macrophage Cells by Bioactive Protein Components

B Yang, J Wang, H Jiang, H Lin, Z Ou, A Ullah… - Frontiers in …, 2021 - frontiersin.org
Extracellular vesicles (EVs) loaded with proteins, nucleic acids, membrane lipids, and other
virulence factors could participate in pathogenic processes in some fungi such as …