Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Metastasis is an evolutionary process occurring across multiple organs and timescales. Due
to its continuous and dynamic nature, this multifaceted process has been challenging to …

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited
treatment options. Here we undertake comprehensive proteomic profiling of tumour …

Despite major progress in breast cancer research, the functional contribution of distinct
cancer cell clones to malignant tumor progression and metastasis remains largely elusive …

A unifying feature of the RAS superfamily is a conserved GTPase cycle by which these
proteins transition between active and inactive states. We demonstrate that …

Our understanding of the cellular composition and architecture of cancer has primarily
advanced using 2D models and thin slice samples. This has granted spatial information on …

Epithelial cancers have served as a paradigm to study tumor dissemination but recent data
have highlighted significant differences with nonepithelial cancers. Here, we review the …

RECK encodes a membrane-anchored protease-regulator which is often downregulated in
a wide variety of cancers, and reduced RECK expression often correlates with poorer …

Understanding how an adult brain reaches an appropriate size and cell composition from a
pool of progenitors that proliferates and differentiates is a key question in Developmental …

Soft-tissue sarcomas (STS) are rare malignancies showing lineage differentiation toward
diverse mesenchymal tissues. Half of all high-grade STSs develop lung metastasis with a …