Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

In addition to the well-known function of ACTH as the main regulator of adrenal
steroidogenesis, we have previously demonstrated its effect on the transcriptional …

Disruption of gene silencing by Polycomb protein complexes leads to homeotic
transformations and altered developmental-phase identity in plants,,,,. Here we define short …

The TIS21 immediate-early gene and leukemia-associated BTG1 gene encode proteins with
similar sequences. Two-hybrid analysis identified a protein that interacts with TIS21 and …

We have used the expression of the human estrogen receptor (hER) and two estrogen
response elements linked to the lacZ gene in yeast (YES) to study the estrogenic and …

Background & Aims: Trefoil factors (TFFs) are secreted gastrointestinal proteins that have
been shown to protect and promote healing of the gastrointestinal tract. Moreover, pS2/TFF1 …

The transcriptional activity of ERα (or NR3A1) after binding of ligand is mediated through
synergistic action between activation functions (AFs) AF-1 and AF-2 and the transcriptional …

Nuclear receptors form strong dimers that are essential for their function as transcription
factors, and it is thought that ligand binding can affect dimer stability. In this report, we …

Reproductive function is regulated by the secretion of luteinizing hormone (LH) and follicle-
stimulating hormone from the pituitary and the steroid hormones from the gonads. The …

A mathematical model was created to examine how xenobiotic ligands that bind to nuclear
receptor proteins may affect transcriptional activation of hormone-regulated genes. The …