[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
[HTML][HTML] Advances in nanomaterial-based targeted drug delivery systems
X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
[HTML][HTML] Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
L Wu, L Wang, X Liu, Y Bai, R Wu, X Li, Y Mao… - … Pharmaceutica Sinica B, 2022 - Elsevier
As endogenous courier vesicles, exosomes play crucial roles in macromolecule
transmission and intercellular communication. Therefore, exosomes have drawn increasing …
transmission and intercellular communication. Therefore, exosomes have drawn increasing …
Engineering nano‐and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport
YB Miao, YJ Lin, KH Chen, PK Luo… - Advanced …, 2021 - Wiley Online Library
Targeted oral delivery of a drug via the intestinal lymphatic system (ILS) has the advantages
of protecting against hepatic first‐pass metabolism of the drug and improving its …
of protecting against hepatic first‐pass metabolism of the drug and improving its …
Ligand-modified nanocarriers for oral drug delivery: challenges, rational design, and applications
Y Zhang, Y Wang, X Li, D Nie, C Liu, Y Gan - Journal of Controlled Release, 2022 - Elsevier
Ligand-modified nanocarriers (LMNCs) specific to their targets have attracted increasing
interest for enhanced oral drug delivery in recent decades. Although the design of LMNCs …
interest for enhanced oral drug delivery in recent decades. Although the design of LMNCs …
Aggregation and growth mechanism of ovalbumin and sodium carboxymethylcellulose colloidal particles under thermal induction
F Niu, F Gu, M Zhao, Y Gao, W Tu, M Kou… - …, 2023 - ACS Publications
Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared
with different compactness and morphologies by regulating the interaction between proteins …
with different compactness and morphologies by regulating the interaction between proteins …
[HTML][HTML] Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy
YB Miao, T Xu, Y Gong, A Chen, L Zou, T Jiang… - Journal of …, 2023 - Springer
Oral administration is preferred over other drug delivery methods due to its safety, high
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
M Bern, J Nilsen, M Ferrarese, KMK Sand… - Science translational …, 2020 - science.org
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but
the efficiency of unassisted transmucosal transport is poor. To make administration and …
the efficiency of unassisted transmucosal transport is poor. To make administration and …
Smart active-targeting of lipid-polymer hybrid nanoparticles for therapeutic applications: Recent advances and challenges
The advances in producing multifunctional lipid-polymer hybrid nanoparticles (LPHNs) by
combining the biomimetic behavior of liposomes and architectural advantages of polymers …
combining the biomimetic behavior of liposomes and architectural advantages of polymers …