[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

[HTML][HTML] Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

[HTML][HTML] Milk-derived exosomes exhibit versatile effects for improved oral drug delivery

L Wu, L Wang, X Liu, Y Bai, R Wu, X Li, Y Mao… - … Pharmaceutica Sinica B, 2022 - Elsevier
As endogenous courier vesicles, exosomes play crucial roles in macromolecule
transmission and intercellular communication. Therefore, exosomes have drawn increasing …

Engineering nano‐and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport

YB Miao, YJ Lin, KH Chen, PK Luo… - Advanced …, 2021 - Wiley Online Library
Targeted oral delivery of a drug via the intestinal lymphatic system (ILS) has the advantages
of protecting against hepatic first‐pass metabolism of the drug and improving its …

Ligand-modified nanocarriers for oral drug delivery: challenges, rational design, and applications

Y Zhang, Y Wang, X Li, D Nie, C Liu, Y Gan - Journal of Controlled Release, 2022 - Elsevier
Ligand-modified nanocarriers (LMNCs) specific to their targets have attracted increasing
interest for enhanced oral drug delivery in recent decades. Although the design of LMNCs …

Aggregation and growth mechanism of ovalbumin and sodium carboxymethylcellulose colloidal particles under thermal induction

F Niu, F Gu, M Zhao, Y Gao, W Tu, M Kou… - …, 2023 - ACS Publications
Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared
with different compactness and morphologies by regulating the interaction between proteins …

[HTML][HTML] Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

YB Miao, T Xu, Y Gong, A Chen, L Zou, T Jiang… - Journal of …, 2023 - Springer
Oral administration is preferred over other drug delivery methods due to its safety, high
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …

An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics

M Bern, J Nilsen, M Ferrarese, KMK Sand… - Science translational …, 2020 - science.org
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but
the efficiency of unassisted transmucosal transport is poor. To make administration and …

Smart active-targeting of lipid-polymer hybrid nanoparticles for therapeutic applications: Recent advances and challenges

L Khalili, G Dehghan, N Sheibani, A Khataee - International Journal of …, 2022 - Elsevier
The advances in producing multifunctional lipid-polymer hybrid nanoparticles (LPHNs) by
combining the biomimetic behavior of liposomes and architectural advantages of polymers …