Advances in organocatalyzed synthesis of organic compounds

A Zafar, MA Iqbal, G Iram, US Shoukat, F Jamil… - RSC …, 2024 - pubs.rsc.org
The recent advancements in utilizing organocatalysts for the synthesis of organic
compounds have been described in this review by focusing on their simplicity, effectiveness …

Vanillin: a promising biosourced building block for the preparation of various heterocycles

D Gendron - Frontiers in Chemistry, 2022 - frontiersin.org
The preparation of heterocyclic compounds often involves the use of petroleum-based or
non-renewable sources. Considering the actual societal and environmental awareness …

Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with …

VK Nuthakki, S Choudhary, CN Reddy… - ACS chemical …, 2023 - ACS Publications
The complex and multifaceted nature of Alzheimer's disease has brought about a pressing
demand to develop ligands targeting multiple pathways to combat its outrageous …

Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial …

T Amin, RP Sharma, KB Mir, N Slathia… - European Journal of …, 2023 - Elsevier
AKT and ERK 1/2 play a pivotal role in cancer cell survival, proliferation, migration, and
angiogenesis. Therefore, AKT and ERK 1/2 are considered crucial targets for cancer …

An Energetic and Topological Approach to Understanding the Interplay of Noncovalent Interactions in a Series of Crystalline Spiropyrrolizine Compounds

D Tsering, P Dey, KK Kapoor, SK Seth - ACS omega, 2024 - ACS Publications
Synthesis of quinoline-containing spiropyrrolizine was achieved via a 1, 3-dipolar
cycloaddition reaction of azomethine ylide (generated in situ from ninhydrin and l-proline) …

Bromine-Promoted One-Pot Furo[b]annulation and α-C(sp2)-Thiomethylation Cascade of (E)-3-Styrylquinoxalin-2(1H)-ones with Dimethyl Sulfoxide

VA Mamedov, NE Algaeva, VV Syakaev… - The Journal of …, 2022 - ACS Publications
A new process has been developed for the bromine-promoted sequential (sp2) C=(sp2) C
bond functionalization of (E)-3-styrylquinoxalin-2 (1 H)-ones and furo [b] annulation via the 5 …

A General Radical Functionalization of Quinoxalin-2(1H)-ones via a Donor–Acceptor Inversion Strategy

C Niu, J Yang, K Yan, Z Su, B Li… - The Journal of Organic …, 2024 - ACS Publications
The radical donor–acceptor inversion strategy represents a highly promising approach in
the field of radical chemistry. The present study initially describes a metal-free, versatile, and …

I2/TBHP Reagent System: A Modern Paradigm for Organic Transformations**

N Slathia, A Gupta, KK Kapoor - European Journal of Organic …, 2022 - Wiley Online Library
Molecular iodine in combination with TBHP offers an advanced concept for organic
synthesis and catalysis by improving the selectivity and sustainability of organic …

Synthesis of 2-styryl-quinazoline and 3-styryl-quinoxaline based sulfonate esters via sp 3 C–H activation and their evaluation for α-glucosidase inhibition

N Satyanarayana, BR Sree, K Sathish… - New Journal of …, 2022 - pubs.rsc.org
Synthesis of 2-styryl-quinazolines and 3-styryl-quinoxaline based sulfonates is reported via
sp3 C–H functionalization in the presence of triethylamine (10 mol%). The resulting …

Comprehensive review on versatile pharmacology of quinoxaline derivative

V Bala Aakash, N Ramalakshmi… - Russian Journal of …, 2022 - Springer
Quinoxaline is a nitrogen-containing heterocyclic compound having many pharmaceutical
and industrial purposes. It can be synthesized by adopting green chemistry principles. The …