[HTML][HTML] The safety and anti-ageing effects of nicotinamide mononucleotide in human clinical trials: an update

Q Song, X Zhou, K Xu, S Liu, X Zhu, J Yang - Advances in nutrition, 2023 - Elsevier
The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …

Self-assembly systems to troubleshoot metabolic engineering challenges

Z Chen, T Wu, S Yu, M Li, X Fan, YX Huo - Trends in Biotechnology, 2024 - cell.com
Enzyme self-assembly is a technology in which enzyme units can aggregate into ordered
macromolecules, assisted by scaffolds. In metabolic engineering, self-assembly strategies …

Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide

Z Huang, N Li, S Yu, W Zhang, T Zhang… - ACS Synthetic …, 2022 - ACS Publications
Research studies on NAD+ have proven its crucial role in aging and disease. Nicotinamide
mononucleotide (NMN), as the key intermediate of NAD+, plays a significant role in …

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

L Zhang, E King, WB Black, CM Heckmann… - Nature …, 2022 - nature.com
Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …

A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy

SR Kafle, A Kushwaha, L Goswami, A Maharjan… - Bioresource …, 2023 - Elsevier
Nicotinamide mononucleotide (NMN) subsists in all living organisms and has drawn
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …

Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase

E King, S Maxel, Y Zhang, KC Kenney, Y Cui… - Nature …, 2022 - nature.com
Noncanonical cofactor biomimetics (NCBs) such as nicotinamide mononucleotide (NMN+)
provide enhanced scalability for biomanufacturing. However, engineering enzymes to …

Yeast cell surface engineering of a nicotinamide riboside kinase for the production of β-nicotinamide mononucleotide via whole-cell catalysis

Z He, X Yang, X Tian, L Li, M Liu - ACS Synthetic Biology, 2022 - ACS Publications
β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-
medication. The one-step conversion of nicotinamide riboside (NR) to β-NMN has been …

Technology and functional insights into the nicotinamide mononucleotide for human health

Y Liu, JS Gong, G Marshall, C Su, JS Shi… - Applied Microbiology and …, 2023 - Springer
Nicotinamide mononucleotide (NMN), a naturally occurring biologically active nucleotide,
mainly functions via mediating the biosynthesis of NAD+. In recent years, its excellent …

[HTML][HTML] Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging

SU Rahman, A Qadeer, Z Wu - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Nicotinamide adenine dinucleotide (NAD+) has recently attracted much attention due to its
role in aging and lifespan extension. NAD+ directly and indirectly affects many cellular …

Biosynthesis of nicotinamide mononucleotide: Current metabolic engineering strategies, challenges, and prospects

S Luo, J Zhao, Y Zheng, T Chen, Z Wang - Fermentation, 2023 - mdpi.com
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine
dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries …