In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Combining physical exercise with cognitive training is a popular intervention in dementia
prevention trials and guidelines. However, it remains unclear what combination strategies …

The reconceptualization of Alzheimer's disease (AD) as a clinical and biological construct
has facilitated the development of biomarker-guided, pathway-based targeted therapies …

Ageing of the population, together with population growth, has brought along an ample
increase in the number of older individuals living with dementia and disabilities. Dementia is …

By 2050, 20% of the world's population will be over the age of 65 years, with projections that
80% of older adults will be living in low-to middle-income countries. Physical inactivity and …

In India, increasing lifespan and decreasing fertility rates have resulted in a growing number
of older persons. By 2050, people over 60 years of age are predicted to constitute 19.1% of …

Aims: This study aimed to describe how the first phase of the coronavirus disease 2019
(COVID-19) pandemic affected older persons from the general Finnish population who are …

The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …

Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive
decline and dementia onset by intervening before significant neuronal damage occurs. In …