Alzheimer's disease

P Scheltens, B De Strooper, M Kivipelto, H Holstege… - The Lancet, 2021 - thelancet.com
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

LJ Dominguez, N Veronese, L Vernuccio, G Catanese… - Nutrients, 2021 - mdpi.com
Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Active aging and public health: evidence, implications, and opportunities

S Dogra, DW Dunstan, T Sugiyama… - Annual review of …, 2022 - annualreviews.org
By 2050, 20% of the world's population will be over the age of 65 years, with projections that
80% of older adults will be living in low-to middle-income countries. Physical inactivity and …

Designing the next-generation clinical care pathway for Alzheimer's disease

H Hampel, R Au, S Mattke, WM van der Flier, P Aisen… - Nature Aging, 2022 - nature.com
The reconceptualization of Alzheimer's disease (AD) as a clinical and biological construct
has facilitated the development of biomarker-guided, pathway-based targeted therapies …

Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized …

HM Gavelin, C Dong, R Minkov, A Bahar-Fuchs… - Ageing research …, 2021 - Elsevier
Combining physical exercise with cognitive training is a popular intervention in dementia
prevention trials and guidelines. However, it remains unclear what combination strategies …

[HTML][HTML] Dementia prevention in memory clinics: recommendations from the European task force for brain health services

GB Frisoni, D Altomare, F Ribaldi, N Villain… - The Lancet Regional …, 2023 - thelancet.com
Observational population studies indicate that prevention of dementia and cognitive decline
is being accomplished, possibly as an unintended result of better vascular prevention and …

Mental health care for older adults: recent advances and new directions in clinical practice and research

CF Reynolds 3rd, DV Jeste, PS Sachdev… - World …, 2022 - Wiley Online Library
The world's population is aging, bringing about an ever‐greater burden of mental disorders
in older adults. Given multimorbidities, the mental health care of these people and their …

Changing demography and the challenge of dementia in India

V Ravindranath, JS Sundarakumar - Nature Reviews Neurology, 2021 - nature.com
In India, increasing lifespan and decreasing fertility rates have resulted in a growing number
of older persons. By 2050, people over 60 years of age are predicted to constitute 19.1% of …

Towards a future where Alzheimer's disease pathology is stopped before the onset of dementia

WM van der Flier, ME de Vugt, EMA Smets, M Blom… - Nature aging, 2023 - nature.com
Alzheimer's disease (AD) is a major healthcare challenge with no curative treatment at
present. To address this challenge, we need a paradigm shift, where we focus on pre …

How can dementia and disability be prevented in older adults: where are we today and where are we going?

I Lisko, J Kulmala, M Annetorp… - Journal of internal …, 2021 - Wiley Online Library
Ageing of the population, together with population growth, has brought along an ample
increase in the number of older individuals living with dementia and disabilities. Dementia is …