The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized
functions in transcriptional regulation, initiation of DNA replication and partitioning the viral …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

In the early stages of human papillomavirus (HPV) infection, the viral proteins elicit specific
immune responses that can participate to regression of ano-genital lesions. HPV E6 protein …

Human papillomaviruses (HPVs) are causative agents in ano-genital and oropharyngeal
cancers. The virus must reprogram host gene expression to promote infection, and E6 and …

Infection with genus beta human papillomaviruses (HPV) is implicated in the development of
non-melanoma skin cancer. This was first evidenced for HPV5 and 8 in patients with …

In many tumors, the switch from precancerous lesions to malignancy critically relies on
expression of the matrix-metalloprotease MMP-9, which is predominantly provided by …

Abstract Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and
transcriptional regulator that recruits sequence-specific transcription factors and chromatin …

Among FOS-related components of the dimeric AP-1 transcription factor, the oncoprotein
FRA-1 (encoded by FOSL1) is a key regulator of invasion and metastasis. The well …

Patients suffering from Epidermodysplasia verruciformis (EV), a rare inherited skin disease,
display a particular susceptibility to persistent infection with cutaneous genus beta-human …

Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers,
including cervical and oropharyngeal. A feature of HPV cancers is their better clinical …