NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …
every living cell, is involved in a myriad of metabolic processes associated with cellular …
NAD (H) and NADP (H) redox couples and cellular energy metabolism
W Xiao, RS Wang, DE Handy… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
NAD metabolism: Implications in aging and longevity
K Yaku, K Okabe, T Nakagawa - Ageing research reviews, 2018 - Elsevier
Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …
physiological processes, including metabolism, post-translational protein modification, and …
The NAD metabolome—a key determinant of cancer cell biology
A Chiarugi, C Dölle, R Felici, M Ziegler - Nature Reviews Cancer, 2012 - nature.com
NAD is a vital molecule in all organisms. It is a key component of both energy and signal
transduction—processes that undergo crucial changes in cancer cells. NAD+-dependent …
transduction—processes that undergo crucial changes in cancer cells. NAD+-dependent …
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
RH Houtkooper, C Cantó, RJ Wanders… - Endocrine …, 2010 - academic.oup.com
A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
W Ying - Antioxidants & redox signaling, 2008 - liebertpub.com
C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …
Structural and mechanistic regulation of the pro-degenerative NAD hydrolase SARM1
M Bratkowski, T Xie, DA Thayer, S Lad, P Mathur… - Cell reports, 2020 - cell.com
The NADase SARM1 is a central switch in injury-activated axon degeneration, an early
hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo …
hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo …