Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
M Levin - Molecular biology of the cell, 2014 - Am Soc Cell Biol
In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
Glutamate and its receptors in cancer
A Stepulak, R Rola, K Polberg… - Journal of neural …, 2014 - Springer
Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …
Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis
HI Wettersten, AA Hakimi, D Morin, C Bianchi… - Cancer research, 2015 - AACR
Kidney cancer [or renal cell carcinoma (RCC)] is known as “the internist's tumor” because it
has protean systemic manifestations, suggesting that it utilizes complex, nonphysiologic …
has protean systemic manifestations, suggesting that it utilizes complex, nonphysiologic …
[HTML][HTML] Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement …
CC Pritchard, SJ Salipante, K Koehler, C Smith… - The Journal of Molecular …, 2014 - Elsevier
Recent years have seen development and implementation of anticancer therapies targeted
to particular gene mutations, but methods to assay clinical cancer specimens in a …
to particular gene mutations, but methods to assay clinical cancer specimens in a …
Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals
Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …
the shortest and longest living species. This natural difference may uncover the evolutionary …
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self
M Levin - Progress in biophysics and molecular biology, 2021 - Elsevier
One lens with which to understand the complex phenomenon of cancer is that of
developmental biology. Cancer is the inevitable consequence of a breakdown of the …
developmental biology. Cancer is the inevitable consequence of a breakdown of the …
Metabotropic glutamate receptors in cancer
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic
signaling. However, accumulating evidence suggests roles of mGluRs in human …
signaling. However, accumulating evidence suggests roles of mGluRs in human …
[HTML][HTML] Endogenous voltage potentials and the microenvironment: bioelectric signals that reveal, induce and normalize cancer
Cancer may be a disease of geometry: a misregulation of the field of information that
orchestrates individual cells' activities towards normal anatomy. Recent work identified …
orchestrates individual cells' activities towards normal anatomy. Recent work identified …
[HTML][HTML] Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications
SS Willard, S Koochekpour - International journal of biological …, 2013 - ncbi.nlm.nih.gov
Glutamate, a nonessential amino acid, is the major excitatory neurotransmitter in the central
nervous system. As such, glutamate has been shown to play a role in not only neural …
nervous system. As such, glutamate has been shown to play a role in not only neural …
Glutamate in peripheral organs: Biology and pharmacology
J Du, XH Li, YJ Li - European journal of pharmacology, 2016 - Elsevier
Glutamate is a versatile molecule existing in both the central nervous system and peripheral
organs. Previous studies have mainly focussed on the biological effect of glutamate in the …
organs. Previous studies have mainly focussed on the biological effect of glutamate in the …