While fruits and vegetables are recommended for prevention of cancer and other diseases,
their active ingredients (at the molecular level) and their mechanisms of action less well …

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa),
a spice often found in curry powder. Traditionally known for its an antiinflammatory effects …

Extensive scientific research on curcumin, a natural compound present in the rhizomes of
plant Curcuma longa Linn., demonstrated its antiinflammatory action. Curcumin was found to …

Phagocytosis of apoptotic cells by macrophages results in the production of transforming
growth factor-β (TGF-β), which plays an important role in induction of an anti-inflammatory …

Loss of glycogen synthase kinase 3β (GSK-3β) in mice results in embryonic lethality via
hepatocyte apoptosis. Consistent with this result, cells from these mice have diminished …

The cellular mechanisms by which prions cause neurological dysfunction are poorly
understood. To address this issue, we have been using cultured cells to analyze the …

Stratified epithelia of the oral cavity are continually exposed to bacterial challenge that is
initially resisted by neutrophils and epithelial factors, including antimicrobial peptides of the …

There is no doubt that diet could effectively improve health and halt cancers. Dietary
phytochemical compounds and their derivatives represent a cornucopia of effectively …

Polymorphonuclear leukocytes (neutrophils) respond to lipopolysaccharide (LPS) through
the up-regulation of several pro-inflammatory mediators. We have recently shown that LPS …

The transcription factor c‐Jun regulates the expression of genes involved in proliferation and
inflammation in many cell types but its role in human renal disease is largely unclear. In the …