Waves in embryonic development

S Di Talia, M Vergassola - Annual review of biophysics, 2022 - annualreviews.org
Embryonic development hinges on effective coordination of molecular events across space
and time. Waves have recently emerged as constituting an ubiquitous mechanism that …

[HTML][HTML] Signalling dynamics, cell decisions, and homeostatic control in health and disease

PO Valls, A Esposito - Current Opinion in Cell Biology, 2022 - Elsevier
Cell signalling engenders cells with the capability to receive and process information from
the intracellular and extracellular environments, trigger and execute biological responses …

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

EH Brumbaugh-Reed, Y Gao, K Aoki… - Nature …, 2024 - nature.com
Biomolecular condensates are broadly implicated in both normal cellular regulation and
disease. Consequently, several chemical biology and optogenetic approaches have been …

Light-switchable transcription factors obtained by direct screening in mammalian cells

L Zhu, HM McNamara, JE Toettcher - Nature communications, 2023 - nature.com
Optogenetic tools can provide fine spatial and temporal control over many biological
processes. Yet the development of new light-switchable protein variants remains …

Optogenetic methods in plant biology

KR Konrad, S Gao, MD Zurbriggen… - Annual Review of Plant …, 2023 - annualreviews.org
Optogenetics is a technique employing natural or genetically engineered photoreceptors in
transgene organisms to manipulate biological activities with light. Light can be turned on or …

[HTML][HTML] Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation

AP Singh, P Wu, S Ryabichko, J Raimundo, M Swan… - Cell reports, 2022 - cell.com
Developmental patterning networks are regulated by multiple inputs and feedback
connections that rapidly reshape gene expression, limiting the information that can be …

Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems

HM McNamara, B Ramm, JE Toettcher - Seminars in cell & developmental …, 2023 - Elsevier
Technological advances have driven many recent advances in developmental biology. Light
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …

Pulling the strings on solid-to-liquid phase transitions in cell collectives

D Pinheiro, J Mitchel - Current Opinion in Cell Biology, 2024 - Elsevier
Cell collectives must dynamically adapt to different biological contexts. For instance, in
homeostatic conditions, epithelia must establish a barrier between body compartments and …

[HTML][HTML] Tug-of-war via ERK signaling pathway for tissue organization–ERK activation to force generation

AN Nayak, T Hirashima - Current Opinion in Cell Biology, 2023 - Elsevier
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …

Cell cycle control by optogenetically regulated cell cycle inhibitor protein p21

L Lataster, HM Huber, C Böttcher, S Föller, R Takors… - Biology, 2023 - mdpi.com
Simple Summary The cell cycle is divided in four phases, the G1 phase for growth in cell
size and increased protein biosynthesis, the S phase for the synthesis and replication of …