Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is
characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of …

Age is the most important risk factor for cancer, as cancer incidence and mortality increase
with age. However, how molecular alterations in tumours differ among patients of different …

Importance Although aspirin is recommended for the prevention of colorectal cancer (CRC)
among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a …

Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell
functionality. However, a decline of the skin regenerative potential occurs with age. The …

Background and aim Pyroptosis is an inflammatory form of programmed cell death
implicated in inflammation and disease. Moreover, inducing pyroptosis has been …

Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …