Molecular approaches for forensic cell type identification: on mRNA, miRNA, DNA methylation and microbial markers

T Sijen - Forensic Science International: Genetics, 2015 - Elsevier
Human biological traces have the potential to present strong evidence for placing a suspect
at a crime scene. In cases, the activity that led to deposition of an individual's cellular …

Challenges and promise at the interface of metaproteomics and genomics: an overview of recent progress in metaproteogenomic data analysis

H Schiebenhoefer, T Van Den Bossche… - Expert Review of …, 2019 - Taylor & Francis
Introduction: The study of microbial communities based on the combined analysis of
genomic and proteomic data–called metaproteogenomics–has gained increased research …

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome

WB Jin, TT Li, D Huo, S Qu, XV Li, M Arifuzzaman… - Cell, 2022 - cell.com
Hundreds of microbiota genes are associated with host biology/disease. Unraveling the
causal contribution of a microbiota gene to host biology remains difficult because many are …

Thermal proteome profiling in bacteria: probing protein state in vivo

A Mateus, J Bobonis, N Kurzawa, F Stein… - Molecular systems …, 2018 - embopress.org
Increasing antibiotic resistance urges for new technologies for studying microbes and
antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe …

[HTML][HTML] Improved antidepressant remission in major depression via a pharmacokinetic pathway polygene pharmacogenetic report

AB Singh - Clinical Psychopharmacology and Neuroscience, 2015 - ncbi.nlm.nih.gov
Objective Major depressive disorder (MDD) is projected to be a leading cause of disability
globally by 2030. Only a minority of patients remit with antidepressants. If assay of …

ABC transporters: a riddle wrapped in a mystery inside an enigma

PM Jones, ML O'Mara, AM George - Trends in biochemical sciences, 2009 - cell.com
ATP-binding cassette (ABC) transporters form one of the largest and most ancient of protein
families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse …

Use of broad range16S rDNA PCR in clinical microbiology

S Sontakke, MB Cadenas, RG Maggi… - Journal of …, 2009 - Elsevier
Broad range 16S rDNA PCR can be used to facilitate the diagnosis of infectious diseases of
bacterial origin by detecting 16S rDNA sequences in patient samples. Post amplification …

Structures of ABC transporters: handle with care

O Lewinson, C Orelle, MA Seeger - FEBS letters, 2020 - Wiley Online Library
In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a
structural revolution. The importance of structural biology to the development of the field of …

The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation

K Dao Duc, YS Song - PLoS genetics, 2018 - journals.plos.org
Previous studies have shown that translation elongation is regulated by multiple factors, but
the observed heterogeneity remains only partially explained. To dissect quantitatively the …

Survival, DNA, and ultrastructural integrity of a cryptoendolithic Antarctic fungus in Mars and Lunar rock analogs exposed outside the International Space Station

S Onofri, L Selbmann, C Pacelli, L Zucconi… - Astrobiology, 2019 - liebertpub.com
The search for life beyond Earth involves investigation into the responses of model
organisms to the deleterious effects of space. In the frame of the BIOlogy and Mars …