Drugging the efferocytosis process: concepts and opportunities

P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

Immune evasion and provocation by Mycobacterium tuberculosis

P Chandra, SJ Grigsby, JA Philips - Nature Reviews Microbiology, 2022 - nature.com
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Efferocytosis in health and disease

AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Autophagy restricts Mycobacterium tuberculosis during acute infection in mice

GR Golovkine, AW Roberts, HM Morrison… - Nature …, 2023 - nature.com
Whether or not autophagy has a role in defence against Mycobacterium tuberculosis
infection remains unresolved. Previously, conditional knockdown of the core autophagy …

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

CJ Queval, R Brosch, R Simeone - Frontiers in microbiology, 2017 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway

Z Qu, J Zhou, Y Zhou, Y Xie, Y Jiang, J Wu, Z Luo… - Science …, 2020 - science.org
Pyroptosis, an inflammatory form of programmed cell death, has been implicated in
eliminating pathogenic infections. However, macrophage pyroptosis–related proteins from …

Neutrophils in tuberculosis-associated inflammation and lung pathology

CN Muefong, JS Sutherland - Frontiers in immunology, 2020 - frontiersin.org
Protective immunity to Mycobacterium tuberculosis (Mtb)—the causative agent of
tuberculosis (TB)—is not fully understood but involves immune responses within the …

Clinical manifestations and immune response to tuberculosis

ML Carabalí-Isajar, OH Rodríguez-Bejarano… - World Journal of …, 2023 - Springer
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection

A Nisa, FC Kipper, D Panigrahy… - … of Physiology-Cell …, 2022 - journals.physiology.org
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …