Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca2+) from intracellular
stores into the cytosol, which is essential for numerous cellular functions including excitation …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one
in ten people. Patients suffering from severe AD eventually progress to develop asthma and …

Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …