MYOD is a master regulator of the skeletal myogenic program. But what regulates
expression of Myod? More than 20 years ago, studies established that Myod expression is …

Abstract ETP-ALL (Early T cell Progenitor Acute Lymphoblastic Leukemia) represents a high-
risk subtype of T cell acute lymphocytic leukemia (T-ALL). Therapeutically, ETP-ALL patients …

Lysine methylation signaling is well studied for its key roles in the regulation of transcription
states through modifications on histone proteins. While histone lysine methylation has been …

Tri-methylation on histone H3 lysine 4 (H3K4me3) is associated with active gene expression
but its regulatory role in transcriptional activation is unclear. Here we used Caenorhabditis …

The emerging appreciation of plasticity among pancreatic lineages has created interest in
harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current …

Molecular regulation of stem cell differentiation is exerted through both genetic and
epigenetic determinants over distal regulatory or enhancer regions. Understanding the …

The skeletal muscle is considered to be an ideal target for stem cell therapy as it has an
inherent regenerative capacity. Upon injury, the satellite cells, muscle stem cells that reside …

Skeletal muscle dysfunction and mass loss is a characteristic feature in patients with chronic
diseases including cancer and acute conditions such as critical illness. Maintenance of an …

Epigenetic mechanisms help the chromatin organize and regulate complex genomes by
governing access to the cellular machinery and fine-tuning gene expression. Genome …

The transcriptional activity of Transposable Elements (TEs) has been involved in numerous
pathological processes, including neurodegenerative diseases such as amyotrophic lateral …