Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome
integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment …

Studies of 3D chromatin organization have suggested that chromosomes are hierarchically
organized into large compartments composed of smaller domains called topologically …

Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory …

Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication
forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss …

Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …