Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

OJ McElvaney, GF Curley, S Rose-John… - The Lancet …, 2021 - thelancet.com
Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors

S Kaur, Y Bansal, R Kumar, G Bansal - Bioorganic & medicinal chemistry, 2020 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

The complex role of adipokines in obesity, inflammation, and autoimmunity

EB Taylor - Clinical Science, 2021 - portlandpress.com
The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Interleukin-6: designing specific therapeutics for a complex cytokine

C Garbers, S Heink, T Korn, S Rose-John - Nature reviews Drug …, 2018 - nature.com
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

M Del Giudice, SW Gangestad - Brain, behavior, and immunity, 2018 - Elsevier
Behavioral researchers have increasingly become interested in the idea that chronic, low-
grade inflammation is a pathway through which social and behavioral variables exert long …

Interleukin-6 family cytokines

S Rose-John - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

M Aliyu, FT Zohora, AU Anka, K Ali, S Maleknia… - International …, 2022 - Elsevier
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …