A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …

Molecular recognition reagents are key tools for understanding biological processes and are
used universally by scientists to study protein expression, localisation and interactions …

Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

Because of the complexity derived from the existence of various phosphoinositide 3-kinase
(PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

Radiation therapy is a staple cancer treatment approach that has significantly improved local
disease control and the overall survival of cancer patients. However, its efficacy is still limited …