Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
Strategies to improve radiotherapy with targeted drugs
AC Begg, FA Stewart, C Vens - Nature Reviews Cancer, 2011 - nature.com
Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …
Strategies for optimizing the response of cancer and normal tissues to radiation
Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …
the course of their treatment, and the majority of these patients are treated with curative …
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
[HTML][HTML] Affimer proteins are versatile and renewable affinity reagents
C Tiede, R Bedford, SJ Heseltine, G Smith, I Wijetunga… - Elife, 2017 - elifesciences.org
Molecular recognition reagents are key tools for understanding biological processes and are
used universally by scientists to study protein expression, localisation and interactions …
used universally by scientists to study protein expression, localisation and interactions …
Mitogen-activated protein kinases and their role in radiation response
A Munshi, R Ramesh - Genes & cancer, 2013 - journals.sagepub.com
Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …
multiple signaling pathways, leading to either increased cell death or increased cell …
Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy
Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …
BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models
N Liu, BR Rowley, CO Bull, C Schneider… - Molecular cancer …, 2013 - AACR
Because of the complexity derived from the existence of various phosphoinositide 3-kinase
(PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with …
(PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with …
Akt: a double‐edged sword in cell proliferation and genome stability
N Xu, Y Lao, Y Zhang, DA Gillespie - Journal of oncology, 2012 - Wiley Online Library
The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …
[HTML][HTML] Radiation-induced signaling pathways that promote cancer cell survival
AL Hein, MM Ouellette, Y Yan - … journal of oncology, 2014 - spandidos-publications.com
Radiation therapy is a staple cancer treatment approach that has significantly improved local
disease control and the overall survival of cancer patients. However, its efficacy is still limited …
disease control and the overall survival of cancer patients. However, its efficacy is still limited …