Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

During sepsis, the liver plays a key role. It is implicated in the host response, participating in
the clearance of the infectious agents/products. Sepsis also induces liver damage through …

Increased resistance to portal blood flow is the primary factor in the pathophysiology of
portal hypertension, and is mainly determined by the morphological changes occurring in …

Nowadays, liver cancer, cirrhosis and other liverrelated diseases are the fifth most common
cause of mortality in the UK. Furthermore, chronic liver diseases (CLDs) are one of the major …

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

Background & Aims: Intrahepatic vascular resistance is regulated in part by the
vasoconstricting and relaxing effects of compounds such as endothelin and nitric oxide …

Neutrophils are involved in organ damage induced by an excessive acute inflammatory
response after ischemiareperfusion, trauma, and sepsis. In addition to causing vascular …

Hepatic stellate cells are similar to tissue pericytes and have been shown to be contractile.
In this study, we examined the effects of known mediators of stellate cell contraction on …