The ambiguous role of sirtuins in head and neck squamous cell carcinoma
D Ezhilarasan, T Lakshmi, M Subha… - Oral …, 2022 - Wiley Online Library
Oral cancer is one of the most leading cancer responsible for significant morbidity and
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities
The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …
dysfunction has an established and prominent role. This is supported by an already large …
Therapeutic potential and activity modulation of the protein lysine deacylase sirtuin 5
F Fiorentino, C Castiello, A Mai… - Journal of Medicinal …, 2022 - ACS Publications
Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase primarily located in
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …
Novel 1, 4-dihydropyridines as specific binders and activators of SIRT3 impair cell viability and clonogenicity and downregulate hypoxia-induced targets in cancer …
The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
SIRT3 Activation a promise in drug development? New insights into SIRT3 biology and its implications on the drug discovery process
Sirtuins catalyze deacetylation of lysine residues with a NAD+-dependent mechanism. In
mammals, the sirtuin family is composed of seven members, divided into four subclasses …
mammals, the sirtuin family is composed of seven members, divided into four subclasses …
Redox homeostasis in cardiovascular disease: the role of mitochondrial sirtuins
A Zullo, R Guida, R Sciarrillo, FP Mancini - Frontiers in endocrinology, 2022 - frontiersin.org
Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite
successful advances in both pharmacological and lifestyle strategies to fight well …
successful advances in both pharmacological and lifestyle strategies to fight well …
Sirtuins in macrophage immune metabolism: A novel target for cardiovascular disorders
C Xu, J Li, Z Liang, Y Zhong, Z Zhang, X Hu… - International Journal of …, 2023 - Elsevier
Abstract Sirtuins (SIRT1-SIRT7), as a family of NAD+-dependent protein modifying enzymes,
have various catalytic functions, such as deacetylases, dealkalylases, and deribonucleases …
have various catalytic functions, such as deacetylases, dealkalylases, and deribonucleases …
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays
E Abbotto, B Casini, F Piacente, N Scarano, E Cerri… - Pharmaceuticals, 2023 - mdpi.com
Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining
attention for the treatment of different cancer types, but also to contrast neurodegenerative …
attention for the treatment of different cancer types, but also to contrast neurodegenerative …
[HTML][HTML] The role of structural biology in the design of sirtuin activators
Sirtuins are NAD+-dependent protein lysine deacylases and mono-ADP-ribosylases whose
activity regulates different pathways, including DNA damage repair, cell survival and …
activity regulates different pathways, including DNA damage repair, cell survival and …