Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …

Primary aldosteronism (PA) is the main cause of secondary hypertension, resulting from
adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia. Here, we show …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing
adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in …

Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism
and somatic mutations in the KCNJ5 gene, which encodes the G-protein–activated inward …

Primary aldosteronism, the most common secondary form of hypertension, is thought to be
present in≈ 5% to 10% of hypertensive adults. However, recent studies indicate that its …