In the past decade clinical and laboratory studies have led to important new insights into the
biology of chronic myeloid leukemia (CML). Basic science has defined the molecular …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

The Philadelphia chromosome translocation (t [9; 22]) results in the molecular juxtaposition
of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on chromosome 22. BCR …

Activated Ras proteins have either positive or negative effects on the regulation of apoptosis
depending on cell type and other factors. In part, this is due to the ability of Ras to control …

Bcr–Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL)
and chronic myelogenous leukemias (CML). This deregulated tyrosine kinase selectively …

Signal transducer and activator of transcription (STAT) 5 is constitutively activated in
BCR/ABL-expressing cells, but the mechanisms and functional consequences of such …

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder resulting from the
clonal expansion of a transformed multipotent hematopoietic stem cell. CML is a biphasic …

Bcr-Abl is a constitutively active tyrosine kinase that is expressed in Philadelphia
chromosome (Ph 1)-positive human leukemias. Bcr-Abl has been shown to inhibit apoptosis …

Cytokines of the interleukin 6 (IL‐6) family, which activates the signal transducer gp130, are
major survival and growth factors for human multiple myeloma (MM) cells. The signal …

Chronic myelogenous leukemia (CML), characterized by the BCR-ABL gene rearrangement,
has been extensively studied. Significant progress has been made in the area of BCR-ABL …