Two proton pump inhibitors, tenatoprazole and esomeprazole, were previously shown to
inhibit HIV-1 egress by blocking the interaction between Tsg101, a member of the ESCRT-I …

Remdesivir (RDV), a nucleoside analogue prodrug, is used to treat viral diseases including
COVID-19. The drug (RDV) was stressed under acidic, basic and neutral hydrolysis …

Avanafil (AV) is the phosphodiesterase (PDE) type 5 inhibitor drug used in erectile
dysfunction, having pyrrolidine, pyrimidine, carboxamide, and chlorine as functional groups …

Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution.
These drugs induce gastric acid secretion through precise inhibition of the enzyme H+/K+ …

Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers
and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies …

Proton pump inhibitor (PPI)-induced inhibition of dimethylarginine dimethylaminohydrolase
1 (DDAH1), with consequent accumulation of the nitric oxide synthase inhibitor asymmetric …

Regulatory agencies from all over the world have set up stringent guidelines with regard to
drug degradation products due to their toxic effects or carcinogenicity. Lansoprazole, a …

A novel, dual gradient LC method for quantification of vardenafil (VR) and its degradant
products was developed with a multivariate approach. In the QbD approach, primary …

Degradation kinetics of oral anticoagulant rivaroxaban (RIV) was assessed in acid and
alkaline media and while exposed to UVC radiation. Among all stress conditions tested …

Multifunctional drug anisomycin was subjected to forced degradation in accordance with
International Conference on Harmonisation (ICH) guidelines for the first time. The drug was …