Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

The nervous and immune systems have evolved in parallel from the early bilaterians, in
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …

Physical or mental stress leads to neuroplasticity in the brain and increases the risk of
depression and anxiety. Stress exposure causes the dysfunction of peripheral T …

This review aims to point out that chronic stress is able to accelerate the appearance of
Alzheimer's disease (AD), proposing the former as a risk factor for the latter. Firstly, in the …

Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

High trait anxiety is a substantial risk factor for developing anxiety disorders and depression.
While neuroinflammation has been identified to contribute to stress-induced anxiety, little is …

Immune cells display a high degree of phenotypic plasticity, which may facilitate their
participation in both the progression and resolution of injury-induced inflammation. The …

Abstract Although the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prominent
positive effects on the pathophysiology of many neurological disorders, the mechanism of …

The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature
brain are more severe and persistent than TBI in the mature brain. Understanding this …