Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Helium ion beam therapy for the treatment of cancer was one of several developed and
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …

FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …

Simple Summary Although immune checkpoint blockade has yielded unprecedented and
durable responses in cancer patients, the efficacy of this treatment remains limited …

Simple Summary This review presents and summarizes the key components and outcomes
of a novel, unconventional radiation approach aimed to exploit immune-stimulatory radiation …

Hypofractionated radiotherapy is external beam irradiation delivered at higher doses in
fewer fractions than conventional standard radiotherapy, which can stimulate innate and …

Particle Therapy (PT) represents a significant advancement in cancer treatment, precisely
targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth …

Radiation-induced immune effects have been extensively deciphered over the last few
years, leading to the concept of the dual immune effect of radiotherapy with both …

Purpose The assumption that traversal of the cell nucleus by ionizing radiation is a
prerequisite to induce genetic damage, or other important biological responses, has been …