Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure

M Aghapour, P Raee, SJ Moghaddam… - American journal of …, 2018 - atsjournals.org
The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …

Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology

N Rout-Pitt, N Farrow, D Parsons, M Donnelley - Respiratory research, 2018 - Springer
Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

Epithelial–mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease

MK Jolly, C Ward, MS Eapen, S Myers… - Developmental …, 2018 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

MS Eapen, S Myers, EH Walters… - Expert review of …, 2017 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is primarily an airway
condition, which mainly affects cigarette smokers and presents with shortness of breath that …

[HTML][HTML] Phosphodiesterases as therapeutic targets for respiratory diseases

H Zuo, I Cattani-Cavalieri, N Musheshe… - Pharmacology & …, 2019 - Elsevier
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?

A Mottais, L Riberi, A Falco, S Soccal, S Gohy… - International journal of …, 2023 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction

MQ Mahmood, SS Sohal, SD Shukla… - … journal of chronic …, 2015 - Taylor & Francis
Background Small airway fibrosis is the main contributor in airflow obstruction in chronic
obstructive pulmonary disease. Epithelial mesenchymal transition (EMT) has been …

Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease

Y Jiang, X Wang, D Hu - International journal of chronic obstructive …, 2017 - Taylor & Francis
The high incidence of chronic obstructive pulmonary disease (COPD), one of the most
prevalent diseases worldwide, has attracted growing attention. Cigarette smoking is …