Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
Monkeypox: a new threat?
D Kmiec, F Kirchhoff - International journal of molecular sciences, 2022 - mdpi.com
The global vaccination programme against smallpox led to its successful eradication and
averted millions of deaths. Monkeypox virus (MPXV) is a close relative of the Variola …
averted millions of deaths. Monkeypox virus (MPXV) is a close relative of the Variola …
Interplay between SARS-CoV-2 and the type I interferon response
M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens,
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells
A Rebendenne, AL Chaves Valadão, M Tauziet… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …
[HTML][HTML] Detailed dissection and critical evaluation of the Pfizer/BioNTech and Moderna mRNA vaccines
X Xia - Vaccines, 2021 - mdpi.com
The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …
The polybasic cleavage site in SARS-CoV-2 spike modulates viral sensitivity to type I interferon and IFITM2
H Winstone, MJ Lista, AC Reid, C Bouton… - Journal of …, 2021 - Am Soc Microbiol
The cellular entry of severe acute respiratory syndrome-associated coronaviruses types 1
and 2 (SARS-CoV-1 and-2) requires sequential protease processing of the viral spike …
and 2 (SARS-CoV-1 and-2) requires sequential protease processing of the viral spike …
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …
All about the RNA: interferon-stimulated genes that interfere with viral RNA processes
E Yang, MMH Li - Frontiers in immunology, 2020 - frontiersin.org
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
[HTML][HTML] Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …
immune responses but may still be vulnerable to some. Here, we systematically analyze the …