Apocynin is a naturally occurring acetophenone, found in the roots of Apocynum
cannabinum and Picrorhiza kurroa. Various chemical and pharmaceutical modifications …

Class III β-tubulin (βIII-tubulin) is frequently overexpressed in human tumors and is
associated with resistance to microtubule-targeting agents, tumor aggressiveness, and poor …

Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of
cancer as it controls the early step of cell division. In this study, we have screened a series of …

Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …

Design and development of potential pyruvate dehydrogenase kinase 3 (PDK3) inhibitors
have gained attention because of their possible therapeutic uses in lung cancer therapy. In …

Herein, a series of quinazoline and heterocyclic fused pyrimidine analogues were designed
and synthesized based on the X-ray co-crystal structure of lead compound 3a, showing …

A library of new phenstatin based indole linked chalcone compounds (9a-z and 9aa-ad)
were designed and synthesized. Of these, compound 9a with 1-methyl, 2-and 3-methoxy …

Microtubule affinity regulating kinase 4 (MARK4) is a potential drug target for neuronal
disorders and several types of cancers. Filtration of naturally occurring compound libraries …

Preclinical and clinical studies have demonstrated the synergistic effect of microtubule-
targeting agents in combination with Janus kinase 2 (JAK2) inhibitors, prompting the …

During a screening performed by the National Cancer Institute in the 1960s, the terpenoid
paclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung …