Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …

Adaptive thermogenesis by brown adipose tissue (BAT) dissipates calories as heat, making
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …

Haem is an essential prosthetic group of numerous proteins and a central signalling
molecule in many physiologic processes,. The chemical reactivity of haem means that a …

Purpose Brown adipose tissue (BAT) activation in humans has gained interest as a potential
target for treatment of obesity and insulin resistance. In rodents, BAT is primarily induced …

Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all
mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has …

Regarding the enormous interest in brown and brite/beige adipose tissue in the context of
metabolic disease, reliable quantification of thermogenesis in these adipocytes is a central …

Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although
improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms …

There is a rapidly increasing prevalence of obesity and related metabolic disorders such as
type 2 diabetes worldwide. White adipose tissue (WAT) stores excess energy, whereas …

During thermogenic activation, brown adipocytes take up large amounts of glucose. In
addition, cold stimulation leads to an upregulation of glycolytic enzymes. Here we have …

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-
body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation …