Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials

M Ghasemi, E Roshandel, M Mohammadian… - Stem cell research & …, 2023 - Springer
Background Over the past few years, mesenchymal stromal cells (MSCs) have attracted a
great deal of scientific attention owing to their promising results in the treatment of incurable …

Mesenchymal stem cells in multiple sclerosis: recent evidence from pre-clinical to clinical studies

A Gugliandolo, P Bramanti, E Mazzon - International journal of molecular …, 2020 - mdpi.com
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous
system. Nowadays, available therapies for MS can help to manage MS course and …

X-ray-based techniques to study the nano–bio interface

C Sanchez-Cano, RA Alvarez-Puebla, JM Abendroth… - ACS …, 2021 - ACS Publications
X-ray-based analytics are routinely applied in many fields, including physics, chemistry,
materials science, and engineering. The full potential of such techniques in the life sciences …

Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

G Santamaria, E Brandi, PL Vitola, F Grandi… - Cell Death & …, 2021 - nature.com
The multiplicity of systems affected in Alzheimer's disease (AD) brains calls for multi-target
therapies. Although mesenchymal stem cells (MSC) are promising candidates, their clinical …

Dense neuronal reconstruction through X-ray holographic nano-tomography

AT Kuan - Biophysical Journal, 2020 - cell.com
1416-Pos Modulation of Human Stem Cell Derived Neuron Activity through Addition of an
External Conductance using Dynamic Clamp Brian K. Panama1, Leigh Korbel1, Brandon …

Hard X‐ray nanoholotomography: large‐scale, label‐free, 3D neuroimaging beyond optical limit

A Khimchenko, C Bikis, A Pacureanu… - Advanced …, 2018 - Wiley Online Library
There have been great efforts on the nanoscale 3D probing of brain tissues to image
subcellular morphologies. However, limitations in terms of tissue coverage, anisotropic …

Exploring Alzheimer's disease mouse brain through X-ray phase contrast tomography: From the cell to the organ

L Massimi, I Bukreeva, G Santamaria, M Fratini… - NeuroImage, 2019 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder associated with aberrant production of beta-amyloid (Aβ) …

Universal or personalized mesenchymal stem cell therapies: impact of age, sex, and biological source

DM Carp, Y Liang - Cells, 2022 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) hold great promise for the treatment of autoimmune
conditions given their immunomodulatory properties. Based on the low immunogenicity of …

[HTML][HTML] Contrast enhancement for visualizing neuronal cytoarchitecture by propagation-based x-ray phase-contrast tomography

M Töpperwien, A Markus, F Alves, T Salditt - NeuroImage, 2019 - Elsevier
Abstract Knowledge of the three-dimensional (3d) neuronal cytoarchitecture is an important
factor in order to understand the connection between tissue structure and function or to …

Multiscale pink-beam microCT imaging at the ESRF-ID17 biomedical beamline

A Mittone, L Fardin, F Di Lillo, M Fratini… - Journal of …, 2020 - journals.iucr.org
Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both
spatial and temporal resolutions. These challenges require intense photon beams. Filtered …